İki ayrı çalışmanın sonuçlarına göre gece mesaisi ve İnsominia( Uyku bozukluğu) insanlarda kanser gelişiminde rol alabilir.
İlk çalışma gece mesaisinde çalışan kadınlarda meme kanseri riski daha yüksek saptanmış.
Bu çalışmada ayrıca 6 saatten az ve 9 saatten çok uyumak ile meme kanseri arasında ilişki saptanmış
Gece mesai yapan ve uyku shifti olan ve uzun yatan hastalarda bu riski daha fazla
İkinci çalışma FRONTLINE MEDICAL NEWS yayınlandı bu çalışmaya göre;
1,620 kanser olamayan denekte yapılan çalışmaya göre, 15 yıllık bir takip sonrası uyku sorunu bulunanlarda %12.3 oranında kanser geliştiği saptanmış
Günde 5 saat’en az uyuyanlarda yaklaşık olarak uyku sorunu olmayanlara göre2.73 kat artmış bir kanser riski saptamışlar.
Bu risk özelikle depresyon ve uyku bozukluğu olanlarda belirgin olduğu gözlenmiş.
Sonuç olarak; Kanser gelişimini engellemede rol alan melatonin hormonun salınması içi ışıksız ve karanlık odada, uygun süre uyumak gerekir.
Night shift work, sleep duration, daytime napping, and breast cancer risk
Sleep Medicine, 02/20/2015Wang P, et al.
The aim of the study was to evaluate the separate and combined associations of night shift work, sleep duration, and daytime napping with breast cancer risk among Chinese. Sleep problems, including night shift work, shorter and longer sleep duration are associated with an increased breast cancer risk. In particular, the combined effects of night shift work with never daytime napping or longer sleep duration are greater than the independent effects.
• This study conducted face-to-face interviews with 712 women diagnosed with incident invasive breast cancer before treatment and 742 age-matched controls.
• Information on sleep habits, demographic characteristics and suspected or established risk factors of breast cancer were collected from the two groups.
• Multivariate logistic regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CI).
• Night shift work was associated with an increased risk of breast cancer [OR (95%CI): 1.34 (1.05-1.72)].
• Compared to women with sleep duration of 6.1-8.9 h/day, women who had shorter (6.0 h/day) [OR (95%CI): 1.53 (1.10-2.12) and longer (9.0 h/day) sleep duration [OR (95% CI): 1.59 (1.17-2.17)] had an increased risk of breast cancer.
• In addition, daytime napping was associated with a reduced risk of breast cancer among night shift workers [OR (95% CI): 0.57 (0.36-0.90)] but no association was found among women who never had night shift work [OR (95% CI): 1.01 (0.75-1.35)] (P for interaction = 0.054).
• Night shift work and longer sleep duration also synergistically increased breast cancer risk [OR (95% CI): 3.69 (1.94-7.02)] (P for interaction = 0.009).
• Insomnia With Very Short Sleep Duration is a Risk Factor for Cancer
• Frontline Medical News, 2014 Jun 11, S London
• MINNEAPOLIS (FRONTLINE MEDICAL NEWS) – People who have the type of insomnia characterized by a sharply shortened duration of sleep are at increased risk for cancer, a longitudinal cohort study showed.
• In the study of more than 1,600 adults from the general population, those who reported insomnia and slept 5 hours or less per night as determined by polysomnography had more than double the adjusted cancer risk of their insomnia-free counterparts who slept longer. But the association was no longer significant after depression was controlled for.
• “Insomnia with severe short sleep duration is associated with increased risk of cancer, particularly in those with comorbid depression,” commented first author Julio Fernandez-Mendoza, Ph.D., of the sleep research and treatment center, department of psychiatry, Penn State College of Medicine, Hershey.
• Previous research has established a dose-response relationship between objectively measured sleep duration and other adverse health outcomes, he noted. “For us, basically, objective sleep duration is a biomarker, is an assay, is the best we have right now. … These findings expand on our previous studies, and it appears that we can continue using this assay to explore the medical morbidity associated with this insomnia phenotype.”
• In an interview, session cochair Dr. Ruth M. Benca, director of the center for sleep medicine and sleep research at the University of Wisconsin–Madison, commented, “The whole connection between sleep and cancer has now come to the fore with some of the recent studies showing, for example, that sleep apnea seems to be a risk factor for the ultimate development of cancer. And these new data suggest that insomnia, or insomnia and depression, may also play a role. We need more mechanistic studies to understand how those links may work.”
• The picture is complicated by overlaps between apnea and insomnia, she noted. “People with apnea can have high rates of insomnia, and both insomnia and apnea can be associated with fragmented sleep or insufficient sleep. So is it the insufficient sleep that’s a problem? Do hypoxemia and apnea also contribute? There are some animal studies that suggest that hypoxemia is related to cancer progression.”
• In the study, the investigators analyzed data from 1,620 individuals in the Penn State cohort who had no history of cancer at baseline. Insomnia was defined as self-reported insomnia present for at least 1 year, and very short sleep duration was defined as 5 hours or less as determined by polysomnography.
• After a follow-up of about 15 years, 12.3% of the individuals experienced incident cancer, defined as a cancer diagnosis or death from the disease.
• In an analysis adjusted for traditional confounders (sex, age, race, apnea-hypopnea index, body mass index, diabetes, and hypertension), relative to noninsomniacs who slept more than 5 hours nightly, insomniacs who slept 5 hours or less had significant 2.73-fold higher odds of incident cancer.
• However, the association was no longer significant after additional adjustment for depression. “This makes sense because we do know very well two things: the strong association of depression with cancer, and second, the strong association of insomnia with depression. They have a lot in common, particularly inflammation. They have in common fatigue also,” Dr. Fernandez-Mendoza said at the annual meeting of the Associated Professional Sleep Societies.
• Similarly, the association was not significant after additional adjustment for smoking and alcohol use. “That was primarily driven by something that we learned from our natural history papers: Because these are basically behavioral factors, many insomniacs stop smoking or stop using so much alcohol, just related to the sleep hygiene thing,” he commented.
• The investigators have not yet assessed whether insomnia with very short sleep duration is associated with specific types of cancer, according to Dr. Fernandez-Mendoza.
• Of note, insomniacs who slept more than 5 hours did not have elevated odds of cancer. Nor did noninsomniacs who slept 5 hours or less.
• Dr. Fernandez-Mendoza disclosed no relevant conflicts of interest.